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              ENGLISH | 院長信箱 | 書記信箱
              師資隊伍
              李長勇

              1、職稱職務:博士、副教授、碩導、系副主任

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              2、學科專業:生理學

              3、研究方向:肝病的天然免疫學機制

              4、聯系電話:

              5、Emaillichangyong@whu.edu.cn

              6、學習經歷:

              2009年在首都醫科大學細胞生物學專業獲得博士學位。2015.4-2016.4 在美國加州大學洛杉磯分校(UCLA)從事博士后研究。

              7、主要工作經歷與任職

              2011.10-今 武漢大學基礎醫學院生理學系講師、副教授

              2009.8-2011.9 首都醫科大學基礎醫學院細胞生物學系講師

              8、目前主要科學研究領域和興趣

              消化生理(肝病的天然免疫學機制)

              9、教學情況:

              承擔臨床醫學五年制、5+3、八年制和口腔、護理、藥學等專業《生理學》、《組織與功能》、《機能實驗學一》和留學生《Physiology》等課程。

              10、代表性論文

              1) Li C, Zheng S, You H, Liu X, Lin M, Yang L, Li L. Sphingosine 1-phosphate (S1P)/S1P receptors is involved in human liver fibrosis by action on hepatic myofibroblasts motility.J Hepatol2011; 54(6):1205-1213.

              2) Li C, Kong Y, Wang H, Wang S, Yu H, Liu X, Yang L, Jiang X, Li L, Li L. Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis.J Hepatol2009; 50(6):1174-1183.

              3) Li C, Jiang X, Yang L, Liu X, Yue S, Li L. Involvement of sphingosine 1-phosphate (S1P)/S1P(3) signaling in cholestasis-induced liver fibrosis.Am J Pathol2009; 175(4):1464-1472.

              4) Qu M, Cui J, Zhu J, Ma Y, Yuan X, Shi J, Guo D,Li C*(Corresponding author). Bone marrow-derived mesenchymal stem cells suppress NK cell recruitment and activation in PolyI:C-induced liver injury.Biochem Biophys Res Commun 2015; 466(2):173-9.

              5) Li C, Hu M, Wang Y, Lu H, Deng J, Yan X. Hydrogen sulfide preconditioning protects against myocardial ischemia/reperfusion injury in rats through inhibition of endo/sarcoplasmic reticulum stress.Int J Clin Exp Pathol2015; 8(7):7740-51.

              6) Yue S, Zhu J, Zhang M, Li C, Zhou X, Zhou M, Ke M, Busuttil RW, Ying QL, Kupiec-Weglinski JW, Xia Q, Ke B.The myeloid heat shock transcription factor 1/β-catenin axis regulates NLR family, pyrin domain-containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury.Hepatology 2016 Jul 30. doi: 10.1002/hep.28739. [Epub ahead of print]

              7) Han Z, Zhu T, Liu X,Li C, Yue S, Liu X, Yang L, Yang L, Li L. 15-Deoxy-Δ(12,14) -prostaglandin J(2) reduces recruitment of bone marrow-derived monocyte/macrophages in chronic liver injury.Hepatology2012; 56(1):350-360.

              8) Liu X, Yue S,Li C, Yang L, You H, Li L. Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation.J Cell Physiol2011; 226(9):2370-2377.

              9) Liu X, Yu H, Yang L,Li C, Li L. 15-Deoxy-Δ(12,14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines.Eur J Cell Biol2012; 91(8):654-661.

              10) Jiang S, Shi Z,Li C, Ma C, Bai X, Wang C. Hydroxysafflor yellow A attenuates ischemia/reperfusion-induced liver injury by suppressing macrophage activation. Int J Clin Exp Pathol2014; 7(5):2595-2608.

              11) Yang L, Chang N, Liu X, Han Z, Zhu T,Li C, Yang L, Li L. Bone Marrow-Derived Mesenchymal Stem Cells Differentiate to Hepatic Myofibroblasts by Transforming Growth Factor-β1 via Sphingosine Kinase/Sphingosine 1-Phosphate (S1P)/S1P Receptor Axis.Am J Pathol2012; 181(1):85-97.

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