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              ENGLISH | 院長信箱 | 書記信箱
              師資隊伍
              何春江

              1、職稱職務:副教授,博導

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              2、學科專業:遺傳與生物信息學

              3、實驗室位置:基礎醫學院1號2樓東側醫學遺傳學系

              4、聯系電話:027 68759702 (O)

              5、Email:che@whu.edu.cn

              6、學習經歷:

              2003.9 – 2008.6:武漢大學生命科學學院,細胞生物學,博士

              1999.9 – 2003.6:武漢大學生命科學學院,生物技術,學士

              7、主要工作經歷與任職

              2009.2-2012.4 芝加哥大學醫學院血液與腫瘤部 博士后 導師:Jianjun Chen & Janet D. Rowley

              2012.5-2013.12 斯坦福大學醫學院心血管與干細胞研究所 博士后 導師:Joseph Wu

              2014.3至今 武漢大學基礎醫學院 副教授,博士生導師

              8、研究方向:

              開發生物信息學工具和數據庫,結合實驗方法,研究白血病和癌癥轉錄組及免疫組的調控與功能,篩選新的藥物靶點和免疫治療靶標。

              9、學術兼職:

              Nucleic Acids Research, Briefings in Bioinformatics, Genomics, Plos One, Inflammatory Bowel Diseases, Biomed Research International, Current Bioinformatics等SCI期刊審稿人。

              10、獲獎、榮譽:

              2016年獲武漢大學醫學部朱裕璧醫學獎

              2014年入選武漢大學珞珈青年學者

              11、研究資助:

              國家自然科學基金面上項目 circ-AFF2調控PRC2復合物介導的AML發生發展機制研究2019.1- 2022. 12 主持

              國家自然科學基金青年項目LncRNA-LINC01268通過激活HDAC2促進急性髓性白血病增殖的分子機制研究 2016.1-2018.12 主持

              國家科技重大專項 艾滋病和病毒性肝炎等重大傳染病防治(子課題) 基于大數據分析的風險評估和預警預測2018.1-2020.12  骨干

              湖北省自然科學青年基金 基于生物信息學的急性髓性白血病lncRNA與mRNA作用網絡的建立與驗證 2015.1-2016.12 主持

              中央高校自主科研青年項目 基于生物信息學的急性髓性白血病lncRNA與mRNA作用網絡的建立與驗證 2015.1-2016.12 主持

              中央高校自主科研交叉項目 癌癥特異環狀RNA剪切數據庫的構建 2018.1.-2019.12 主持

              12、代表性論著 (*一作,#通訊):


              1. Xiao S*, Cao S*, Huang Q*, Xia L*, Deng M, Yang M, Jia G, Liu X, Shi J, Wang W, Li Y, Liu S, Zhu H, Tan K, Luo Q, Zhong M#, He C#, Xia L#. The RNA N(6)-methyladenosine modification landscape of human fetal tissues. Nature Cell Biology. 2019 Apr 29. doi: 10.1038/s41556-019-0315-4.


              2. Feng J*#, Chen K*, Dong X*, Xu X, Jin Y, Zhang X, Chen W, Han Y, Shao L, Gao Y, He C#. Genome-wide identification of cancer-specific alternative splicing in circRNA. Molecular Cancer. 2019 Mar 8; 18(1):35. doi: 10.1186/s12943-019-0996-0.


              3. Han Y*, Feng J*, Xia L*, Dong X, Zhang X, Zhang S, Miao Y, Xu Q, Xiao S, Zuo Z, Xia L, He C#. CVm6A: A Visualization and Exploration Database for m6As in Cell Lines. Cells. 2019 Feb 17; 8(2). pii: E168. doi: 10.3390/cells8020168.


              4. Feng J*, Xiang Y*, Xia S*, Liu H, Wang J, Ozguc F, Lei L, Kong R, Diao L, He C#, Han L#. CircView: a visualization and exploration tool for circular RNAs. Briefings in Bioinformatics. 2018 Nov 27. doi: 10.1093/bib/bbx070.


              5. Lei L*, Xia S*, Liu D*, Li X*, Feng J, Zhu Y, Hu J, Xia L, Guo L, Chen F, Cheng H, Chen K, Hu H, Chen X, Li F, Zhong S, Mittal N, Yang G, Qian Z, Han L#, He C#. Genome-wide characterization of lncRNAs in acute myeloid leukemia. Briefings in Bioinformatics. 2018 Jun 20. doi: 10.1093/bib/bbx007.


              6. Xia S*, Feng J*, Chen K*, Ma Y, Gong J, Cai F, Jin Y, Gao Y, Xia L, Chang H, Wei L, Han L#, He C#. CSCD: A database for cancer-specific circular RNAs. Nucleic Acids Research. 2018 Jan 4. doi: 10.1093/nar/gkx863. WOS高被引論文


              7. Xia S*, Feng J*, Lei L, Hu J, Xia L, Wang J, Xiang Y, Liu L, Zhong S, Han L#, He C#. Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Briefings in Bioinformatics. 2017 Nov 1. doi: 10.1093/bib/bbw081. WOS高被引論文


              8. He C*#, Hu H*, Wilson KD*, Wu H, Feng J, Xia S, Churko J, Qu K, Chang HY, Wu JC#. Systematic Characterization of Long Non-Coding RNAs Reveals the Contrasting Coordination of Cis- and Trans- Molecular Regulation in Human Fetal and Adult Heart. Circulation Cardiovascular Genetics. 2016 Apr. pii: CIRCGENETICS.115.001264.


              9. Li Z*, Herold T*, He C*, Valk PJ, Chen P, Jurinovic V, Mansmann U, Radmacher MD, Maharry KS, Sun M, Yang X, Huang H, Jiang X, Sauerland MC, Büchner T, Hiddemann W, Elkahloun A, Neilly MB, Zhang Y, Larson RA, Le Beau MM, Caligiuri MA, D?hner K, Bullinger L, Liu PP, Delwel R, Marcucci G, Lowenberg B, Bloomfield CD, Rowley JD, Bohlander SK, Chen J. Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study. Journal of Clinical Oncology. 2013 Mar 20;31(9):1172-81. doi: 10.1200/JCO.2012.44.3184.


              10. He C*, Li Z*, Chen P*, Huang H, Hurst LD, Chen J. Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution. Nucleic Acids Research. 2012 May;40(9):4002-12. doi: 10.1093/nar/gkr1312.


              11. Mi S*, Li Z*, Chen P*, He C*, Cao D, Elkahloun A, Lu J, Pelloso LA, Wunderlich M, Huang H, Luo RT, Sun M, He M, Neilly MB, Zeleznik-Le NJ, Thirman MJ, Mulloy JC, Liu PP, Rowley JD, Chen J. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3710-5. doi: 10.1073/pnas.0914900107.


              12. He C*, Zhou F, Zuo Z, Cheng H, Zhou R. A global view of cancer-specific transcript variants by subtractive transcriptome-wide analysis. PLoS One. 2009;4(3):e4732. doi: 10.1371/journal.pone.0004732.


              13. He C*, Cheng H, Zhou R. GATA family of transcription factors of vertebrates: phylogenetics and chromosomal synteny. Journal of Biosciences. 2007 Dec;32(7):1273-80.


              14. He C*, Zuo Z, Chen H, Zhang L, Zhou F, Cheng H, Zhou R. Genome-wide detection of testis- and testicular cancer-specific alternative splicing. Carcinogenesis. 2007 Dec;28(12):2484-90.


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