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              ENGLISH | 院長信箱 | 書記信箱
              師資隊伍
              汪長華

              1、職稱職務教授、博導、教研室主任68B92、學科專業:病理生理學

              3、研究方向:代謝性疾病的分子機制

              4、實驗室位置:基礎醫學院1號樓3樓

              5、Email:chwang0525@whu.edu.cn

              6、學習經歷:

              1998.09 – 2001.06 武漢大學醫學院,內科學,博士

              1988.09-1991.06 湖北醫科大學,病理生理學,碩士

              1983.09-1988.06 湖北醫科大學,臨床醫學,學士

              7、主要工作經歷與任職:

              2001.06~至今 武漢大學基礎醫學院,副教授、教授,教研室副主任、主任

              2014.01 – 2015.08 The University of South Dakota Sanford Medical College,Assistant Professor Research

              2010.10 – 2011.09 The University of South Dakota Sanford Medical College,Visiting Research Scientist

              2004.07 – 2008.09 University of Texas Health Science Center at San Antonio,Research Scientist

              2003.04 – 2003.08 Henri Poincare Université, Nancy 1, Visiting Associate Professor

              1993.01 – 1998.08 長江大學醫學院,副教授

              1991.07 – 1992.12 荊州市第一人民醫院,主治醫師

              8、目前主要科學研究領域和興趣:

              研究重點集中在闡明代謝性疾病發生、發展的分子機制。率先揭示了脂聯素 (adiponectin) 信號轉導、及其胰島素增敏效應的分子機制,其關鍵論文均發表在著名的J Biol. Chem.雜志上,單篇第一作者SCI論文它引次數已達177次(Goggle citation; 2017-01-30)。由于代謝異常是心血管疾病、腫瘤等疾病發生的獨立危險因素,本課題組也展開了對代謝異常與心肌病、乳腺癌、肝癌間相關性的研究。研究領域包括: (1)糖尿病發生發展的分子機制,(2)糖尿病心肌病的分子機制,(3)代謝異常與乳腺癌、肝癌相關性研究。先后主持國家自然科學基金項目3項,公開發表SCI收錄學術論文40余篇。

              9、主要學術兼職:

              Frontiers in Pharmacology - Section “Cardiovascular and Smooth Muscle Pharmacology”,Associate Editor

              10、教學情況:

              承擔醫學相關專業本科生(含五年制、七年制、八年制各專業)、碩士生、博士生等不同層次學生的病理生理學理論和實驗教學工作。培養病理生理學碩士、博士研究生。

              11、獲獎及榮譽:

              12、近五年主要代表性論文:

              1.  Li M, Zhang Y, Cao Y, Zhang D, Liu L, Guo Y, Wang C*. Icariin ameliorates palmitate-induced insulin resistance through reducing thioredoxin-interacting protein (TXNIP) and suppressing ER stress in C2C12 myotubes. Front. Pharmacol. 2018; 9:1180.

              2. Ye M, Qiu H, Cao Y, Zhang M, Mi Y, Yu J, Wang C*. Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum. Front Pharmacol. 2017;8:148.

              3. Jiang P, Zhang D, Qiu H, Yi X, Zhang Y, Cao Y, Zhao B, Xia Z, Wang C*. Tiron ameliorates high glucose-induced cardiac myocyte apoptosis by PKCδ-dependent inhibition of osteopontin. Clin Exp Pharmacol Physiol. 2017;44(7):760-770.

              4. Ding Y, Zhang D, Wang B, Zhang Y, Wang L, Chen X, Li M, Tang Z, Wang C*. APPL1-mediated activation of STAT3 contributes to inhibitory effect of adiponectin on hepatic gluconeogenesis. Mol Cell Endocrinol. 2016;433:12-19.

              5. Zhang D, Zhang Y, Ye M, Ding Y, Tang Z, Li M, Zhou Y, Wang C*. Interference with Akt signaling pathway contributes curcumin-induced adipocyte insulin resistance. Mol Cell Endocrinol. 2016;429:1-9.

              6. Khan S, Zhang D, Zhang Y, Li M, Wang C*. Wogonin attenuates diabetic cardiomyopathy through its anti-inflammatory and anti-oxidative properties. Mol Cell Endocrinol. 2016;428:101-108.

              7. Guan F, Ding Y, Zhang Y, Zhou Y, Li M, Wang C*. Curcumin Suppresses Proliferation and Migration of MDA-MB-231 Breast Cancer Cells through Autophagy-Dependent Akt Degradation. PLoS One. 2016;11(1):e0146553.

              8. Wang C, Wang X. The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicity. Biochim Biophys Acta. 2015;1852(2):188-194.

              9. Zhang Y, Ye M, Chen LJ, Li M, Tang Z, Wang C*. Role of the ubiquitin-proteasome system and autophagy in regulation of insulin sensitivity in serum-starved 3T3-L1 adipocytes. Endocr J. 2015;62(8):673-686.

              10. Zhang YM, Li MX, Tang Z, Wang CH*. Wogonin suppresses osteopontin expression in adipocytes by activating PPARα. Acta Pharmacol Sin. 2015;36(8):987-997.

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